2-CHLOROETHYL ACETATE
2-chloro ethyl acetate
CAS: 542-58-5
Molecular Formula: C4H7ClO2
2-CHLOROETHYL ACETATE - Names and Identifiers
| Name | 2-chloro ethyl acetate |
| Synonyms | 2-Chlorethylacetat 2-CHLOROETHYL ACETATE 2-chloroethanolacetate 2-chloro-ethanoacetate 2-chloro ethyl acetate 2-Acetoxyethyl chloride 2-Chloroethanol acetate 2-Acetoxy-1-chloroethane 1-Acetoxy-2-chloroethane 2-chloro-1-ethanol acetate ACETIC ACID 2-CHLOROETHYL ESTER |
| CAS | 542-58-5 |
| EINECS | 208-820-2 |
| InChI | InChI=1/C4H7ClO2/c1-4(6)7-3-2-5/h2-3H2,1H3 |
2-CHLOROETHYL ACETATE - Physico-chemical Properties
| Molecular Formula | C4H7ClO2 |
| Molar Mass | 122.55 |
| Density | 1,16 g/cm3 |
| Boling Point | 145°C |
| Flash Point | 54°C |
| Water Solubility | Insoluble in water |
| Vapor Presure | 4.77mmHg at 25°C |
| Appearance | clear liquid |
| Color | Colorless to Light yellow |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.4220-1.4250 |
2-CHLOROETHYL ACETATE - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | R10 - Flammable R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S28 - After contact with skin, wash immediately with plenty of soap-suds. |
| UN IDs | 2929 |
| RTECS | KK1010000 |
| Hazard Class | 6.1/3 |
| Packing Group | II |
2-CHLOROETHYL ACETATE - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | ethyl 2-chloroacetate can be used as an intermediate in pharmaceutical synthesis. |
| Application | It can be used to prepare 3-keto-4-androsten-17β carboxylic acid, including the steps: 1)3 β-diethyl ether -3, 5-androstenodiene-17-one, slowly add 2-chloroacetate ethyl, and undergo addition and cyclition reactions to obtain 3 β-ethyl ether -3, ethyl 5-androstene-17, 20-epoxy-20-carboxylic acid; 2)3 β-ethyl ether -3, 5-androstene-17, 20-epoxy-20-carboxylic acid ethyl ester is decarboxylated and hydrolyzed at high temperature to obtain 3-keto-4-androene-20-aldehyde; 3) 3-keto-4-androten-20-aldehyde is oxidized to obtain 3-keto-4-androten-17β carboxylic acid. The method proposed by the invention changes the synthesis route and the initial synthesis raw material, uses the cheap 4AD derivative raw material 3 β-ether -3, 5-androstene -17-one, reduces the synthesis reaction step, the reaction condition is mild. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD50: 10 mg/kg; Oral-mouse LD50: 250 mg/kg |
| flammability hazard characteristics | flammability; fire scene decomposition of toxic chloride gas |
| storage and transportation characteristics | warehouse is low temperature, ventilated and dry; Fire prevention; Store separately from oxidant and food raw materials |
| fire extinguishing agent | water, carbon dioxide, foam, sand |
Last Update：2024-04-09 02:00:05
